Reviewed by Dr. Meredith Sweeney, MD, FACS, FASMBS | Board-certified bariatric surgeon, A4M member, founder of Sano Longevity in Middletown. Last updated April 2026.
Concierge longevity medicine in Louisville, built around your VO2 max, your metabolism, your body composition, and your blood, by a board-certified surgeon who spent over a decade fixing what metabolic disease breaks.
30-minute call. No obligation. Cash-pay practice, HSA and FSA eligible.
For over a decade, Dr. Meredith Sweeney was a board-certified bariatric surgeon at Norton Healthcare. She spent her days inside the abdomens of patients whose livers were so heavy with fat she needed two retractors to lift them. She could see, with the naked eye, the consequences of metabolic dysfunction that a blood pressure cuff and a 12-minute primary care visit will never catch.
“I could see the consequences of metabolic dysfunction. Yellow droplets and big dilated livers because of all the sugar stored there. I had to physically lift up livers that were sometimes so heavy we had to insert two retractors into the abdomen. Purely because of metabolic dysfunction.”
Dr. Meredith Sweeney, MD, FACS, FASMBS
That sentence is the spine of her clinical authority. Almost no other longevity physician in the country can say it. Most doctors who now market themselves as longevity experts came in through hormone replacement, peptide protocols, or wellness coaching. Dr. Sweeney came in through the operating room. She watched what happens when prevention fails for ten years before she ever wrote her first longevity protocol.
The pivot started in 2018. While still operating full-time at Norton, she began going to conferences on metabolic health and low-carb medicine. She taught herself nutrition. She rewrote the preoperative and postoperative diet protocols at Norton with no formal nutrition credential, because what her patients were being fed before and after surgery was making their outcomes worse. By the time she walked away from her hospital paycheck in late 2023, she was already spending 90% of her time outside the operating room managing the metabolic and lifestyle health of her surgical patients. She was a longevity doctor in everything but title.
“I am a fixer. I start at the bottom and fix it there, and then everything upstream is magically better.”
Dr. Meredith Sweeney
She opened Sano Longevity in March 2025. Her first patient was a scrub tech from Norton who had worked night shifts with her in the OR and had heard her talking about metabolic health for years. He showed up the day the doors opened. He is still a patient today.
In December 2025, less than a year after opening, Dr. Sweeney spoke at Longevity Fest, the largest annual longevity medicine conference in the United States.
Your first appointment captures four data sets that almost no Louisville physician collects in one visit. These four numbers form the spine of your individualized longevity roadmap.
Under 15 minutes on a bike or treadmill. Returns your biological age, your exact training zones, your fat-burning crossover point, and the single most predictive longevity number in cardiovascular medicine.
According to the American Heart Association, VO2 max is the strongest predictor of all-cause mortality.
See VO2 max testing →
PNOĒ metabolic breath analysis. Returns your actual caloric burn at rest, your fat-burn efficiency, and exact protein and carbohydrate targets for workout and non-workout days. Not a formula. A measurement.
See metabolic testing →
Measures where your fat lives, not just how much. Returns visceral fat in square centimeters, segmental muscle mass, and the dangerous fat number that drives chronic disease, lowers testosterone, and ages you from the inside.
See body composition →
Run through Quest Diagnostics. Roughly 20 markers actively drive clinical decisions. Includes fasting insulin, the Omega-3 index, Vitamin D, and the precursor markers your primary care panel does not include.
In her first 125 comprehensive evaluations at Sano, two findings have repeated themselves with alarming consistency:
Every Sano patient gets a plan built on the four things you cannot outsource, outsupplement, or out-hormone your way around.
We measure your resting metabolic rate on the PNOĒ platform and prescribe protein and calories in grams, not platitudes. Your plan is built for workout days and rest days separately.
We measure your VO2 max and give you exact heart rate zones, training splits, and a strength protocol designed to add muscle, not just burn calories. Muscle is the organ of longevity.
We measure your blood markers and your sleep before we touch your hormones. The body cannot heal what your nervous system is still fighting.
We screen for the patterns that age you faster than anything else on the panel, and we build the plan around your reality, not a textbook.
“If you just got off the phone fighting with your wife in the parking lot, I can only give you one task to do for the next three months. We meet you where you are.”
Dr. Meredith Sweeney
These are three Sano Longevity patients in their first six months. Names are withheld. Every number is from their actual reports.
Female, 50, nurse practitioner
She had already maxed out a GLP-1 from an online prescriber. Side effects, zero weight loss. Six months at Sano:
A 33% VO2 max improvement corresponds to a 30 to 45% reduction in all-cause mortality risk per AHA data.
Female, 41, perimenopausal
She walked in and said: “I just want to feel great in my own skin.” Six months later, with a low-dose GLP-1 plus a 90-day continuous glucose monitor protocol:
Male, 51, third shift
His wife noticed him slowing down. We built a protocol around his irregular schedule. Six months in:
When most people lose weight, their metabolism slows down. His sped up. That is the strength training protocol working.
Sano Longevity is a membership practice, not a single-visit clinic. Patients who quit at three months have a 100% failure rate. Patients who commit see results that compound year over year.
12-month commitment
For patients who want to add years to their life and life to their years. Built around quarterly physician appointments, annual labs, unlimited body composition retesting, concierge access by text, email, and phone, and a State of the Union review at the end of year one.
Three tiers available, including options for hormone replacement, peptide protocols, dietitian sessions, and bi-annual VO2 max retesting.
See Longevity Track →
6-month commitment
For patients who have tried online GLP-1 prescribers, primary care advice, and diet apps and need a physician with the testing infrastructure to make it work. Built around a 90-day continuous glucose monitor protocol, body composition monitoring, and physician-supervised GLP-1 prescribing when clinically appropriate.
Two tiers available, including a coaching and dietitian add-on for executive members.
See Weight Loss Track →
Pricing is currently being restructured ahead of an April membership cycle. See our pricing page for current tiers and enrollment fees, or book a free consultation and we will walk you through the right fit for your goals.
You still see yourself the way you did at 22. The mirror is starting to disagree. You want your body composition back, your energy back, and a strength protocol that does not destroy your knees. We give you the data and a plan that fits the life you actually live.
You are doing well professionally and you are watching your mother decline. Dementia is the fear. Strength is the answer. We measure the metabolic markers that drive cognitive aging and build a plan around protecting your brain for the next 30 years.
You finally have the time and the budget to play the long game. You want the next 20 to 30 years to be active, sharp, and on your terms. We build the roadmap that gets you there, and we measure the progress every quarter.
As Featured In
Speaker, Longevity Fest 2025
Dr. Sweeney spoke at Longevity Fest in December 2025, the largest annual longevity medicine conference in the United States, organized by the American Academy of Anti-Aging Medicine.
Sano Longevity sits at 306 Middletown Park Pl Unit D, Louisville, KY 40243, in the heart of the East End corridor. Patients drive in from Norton Commons, St. Matthews, Mockingbird Valley, Indian Hills, Anchorage, Prospect, Lake Forest, and Pewee Valley.
A growing share of our patients cross the bridge from Jeffersonville and New Albany in Southern Indiana, where there is no comparable longevity medicine practice. The drive is 15 to 20 minutes.
Sano Longevity
306 Middletown Park Pl Unit D Louisville, KY 40243 (502) 208-6476 Monday to Thursday, 9am to 4pm Telehealth follow-ups available
Seven questions patients ask most often before booking their first visit.
Longevity medicine identifies the precursors to chronic disease 10 to 20 years before they show up on a standard lab. Primary care checks blood pressure and treats what is already broken. At Sano Longevity, Dr. Meredith Sweeney measures VO2 max, resting metabolic rate, body composition, visceral fat, and a 25-marker blood panel that includes fasting insulin and the Omega-3 index, then builds an individualized plan to reverse risk before it becomes diagnosis.
Dr. Meredith Sweeney is a board-certified bariatric surgeon (MD, FACS, FASMBS) who spent over a decade operating on the consequences of metabolic disease before founding Sano Longevity in March 2025. She is a member of the American Academy of Anti-Aging Medicine and spoke at Longevity Fest in December 2025, the largest annual longevity medicine conference in the United States. Read her full story →
Sano Longevity is cash-pay only. Insurance is not accepted. The practice is HSA and FSA eligible, and payment is by credit card or cash. This model exists so Dr. Sweeney can spend 60 to 90 minutes with you reviewing your data instead of the 12 minutes a typical insurance-billed visit allows.
Your first visit is fasted and in-office. You complete VO2 max testing on a bike or treadmill (under 15 minutes), an InBody 580 body composition scan, resting metabolic rate testing on the PNOĒ platform, and a blood draw that runs through Quest Diagnostics. About one month later, Dr. Sweeney spends 60 to 90 minutes walking you through every result and presenting your individualized longevity roadmap.
In the first 125 patients she has comprehensively evaluated at Sano, roughly 90% had elevated fasting insulin and roughly 90% tested below the longevity-optimal Omega-3 index. Both are markers that primary care almost never tests, because insurance does not reimburse them as screening tests. Dr. Sweeney considers not testing fasting insulin close to malpractice.
Sano Longevity is located at 306 Middletown Park Pl Unit D, Louisville, KY 40243, in the East End corridor. Patients drive in from Norton Commons, St. Matthews, Mockingbird Valley, Indian Hills, Anchorage, Prospect, Lake Forest, Pewee Valley, and from Jeffersonville and New Albany in Southern Indiana.
Sano Longevity offers two membership tracks. The Longevity Track is a 12-month commitment with three tiers. The Weight Loss Track is a 6-month commitment built around a 90-day continuous glucose monitor protocol, body composition monitoring, and physician-supervised GLP-1 prescribing when clinically appropriate. A one-time enrollment fee applies. See the pricing page →
Your first call is free, 30 minutes, and answered by someone who can tell you whether Sano is the right fit before you commit a dollar. Cash-pay practice. HSA and FSA eligible. Same physician every visit.
We respond within 24 hours. No pitch. Just data. Or call (502) 208-6476.
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Reviewed by
Founder, Sano Longevity in Middletown, Louisville. Board-certified bariatric surgeon. Fellow of the American College of Surgeons (FACS) and the American Society for Metabolic and Bariatric Surgery (FASMBS). Member, American Academy of Anti-Aging Medicine (A4M). Speaker, Longevity Fest 2025. More than ten years of metabolic medicine experience at Norton Healthcare before founding Sano Longevity in March 2025.
Sano Longevity
(502) 208-6476