30-minute call. No obligation. Concierge practice, HSA and FSA eligible.
Reviewed by Dr. Meredith Sweeney, MD, FACS, FASMBS | Board-certified bariatric surgeon, A4M member, founder of Sano Longevity in Middletown. Last updated April 2026.
For over a decade, Dr. Meredith Sweeney was a board-certified bariatric surgeon at Norton Healthcare. Her patients were the ones whose metabolic disease had already gone too far. She operated on the consequences of unmanaged insulin resistance, visceral fat, and cardiovascular decline, hundreds of times. She did not read about metabolic dysfunction in a journal. She operated on it.
“I take very complex sets of data and weave them together into an actionable and realistic plan that’s going to move the needle. We have to eat, we have to move our bodies, we have to manage our stress, and we have to sleep. If we do those things with intention and with a data-driven plan, we are going to live longer, more enjoyable lives.” Dr. Meredith Sweeney, MD, FACS, FASMBS
That is not a wellness talking point. It comes from a surgeon who spent a decade in the operating room watching what happens when there is no plan. Most doctors who now market themselves as longevity experts came in through hormone replacement, peptide protocols, or wellness coaching. Dr. Sweeney came in through the operating room. She watched what happens when prevention fails for ten years before she ever wrote her first longevity protocol.
The pivot started in 2018. While still operating full-time at Norton, she began going to conferences on metabolic health and low-carb medicine. She taught herself nutrition. She rewrote the preoperative and postoperative diet protocols at Norton with no formal nutrition credential, because what her patients were being fed before and after surgery was making their outcomes worse. By the time she walked away from her hospital paycheck in late 2023, she was already spending 90% of her time outside the operating room managing the metabolic and lifestyle health of her surgical patients. She was a longevity doctor in everything but title.
“I am a fixer, I always have been, which is why I went into surgery in the first place. At Sano Longevity I still help patients fix their health, I just do it from the ground up.” Dr. Meredith Sweeney
She opened Sano Longevity in March 2025. Her first patient was a scrub tech who had worked night shifts with her in the OR and had heard her talking about metabolic health for years. She showed up the day the doors opened. She is still a patient today.
In December 2025, less than a year after opening, Dr. Sweeney spoke at Longevity Fest, the largest annual longevity medicine conference in the United States.
Practice type Concierge longevity medicine. Membership-based. HSA and FSA eligible
Founder Dr. Meredith Sweeney, MD, FACS, FASMBS, board-certified bariatric surgeon, A4M member
Founded March 2025
Location 306 Middletown Park Pl Unit D, Louisville, KY 40243
Hours Monday to Thursday, 9am to 4pm; telehealth follow-ups available
Testing platform PNOĒ (18-page Biological Age & Performance Analysis from VO2 max and 17-page Metabolic Blueprint from RMR)
VO2 max The single strongest predictor of all-cause mortality, per the American Heart Association
Patient outcome benchmark Average visceral fat reduction of 20+ sq cm in the first 6 months
VO2 max case 33% increase achieved in 6 months by a Sano patient, corresponding to a 30 to 45% reduction in all-cause mortality risk per AHA data
What 90% of new patientswalk in with Elevated fasting insulin (a marker primary care almost never tests)
Second 90% finding An Omega-3 index below the longevity-optimal threshold of 8%
Membership structure Two programs. 12-month Longevity Optimization (Gold $299/mo, Elite $499/mo). 12-month Weight Loss (Gold $349/mo, Elite $499/mo). One-time $350 onboarding across all programs.
Speaking Dr. Sweeney spoke at Longevity Fest 2025 (the largest annual longevity medicine conference in the United States)
Your first appointment captures data sets that almost no Louisville physician collects in one visit. This extensive and cutting edge approach forms the spine of your individualized longevity roadmap.
Under 15 minutes on a bike or treadmill. Determines your biological age, your exact training zones, your fat-burning crossover point, and the single most predictive longevity number in cardiovascular medicine.
According to the American Heart Association, VO2 max is the strongest predictor of all-cause mortality.
Pnoe metabolic breath analysis collects 23 non-invasive biomarkers of longevity. Determines your actual calorie burn at rest, Heart rate variability, fat-burning efficiency, and mitochondrial function. We don’t plug you into an algorithm, we calculate your data.
Measures where your fat lives, not just how much. Determines visceral fat in square centimeters, segmental muscle mass, and the dangerous fat number that drives chronic disease, lowers testosterone, and ages you from the inside.
Run through Quest Diagnostics. The panel includes fasting insulin (the most important biomarker of longevity), the Omega-3 index, Vitamin D, and dozens of precursor markers that traditional healthcare does not include.
In her first 125 comprehensive evaluations at Sano, two findings have repeated themselves with alarming consistency:
Roughly 90% of new patients walk in with elevated fasting insulin. Fasting insulin is the most important biomarker of longevity. Roughly 90% of new patients test below the longevity-optimal Omega-3 index. Standard labs say above 5% is fine. Longevity-grade research says you want above 8%. Almost nobody walks in above 3%.
Using the latest technology, we measure your resting metabolic rate and analyze your metabolic health to personalize a nutrition plan to help you thrive now and for decades to come.
We measure your VO2 max and give you exact heart rate zones, training splits, and a strength protocol designed to add muscle, not just burn calories. Muscle is the organ of longevity.
We collect both subjective and objective measures of stress resilience to optimize your ability to deal with life stressors. The body cannot heal what the nervous system is fighting.
We collect both subjective and objective data to analyze your sleep quality and devise a plan for optimization. You can't perform at your best and optimize your health without adequate quality rest.
These are three Sano Longevity patients in their first six months. Names are withheld. Every number is from their actual reports.
Female, 50, nurse practitioner
She had already maxed out a GLP-1 from an online prescriber. Side effects, zero weight loss. Six months at Sano:
A 33% VO2 max improvement corresponds to a 30 to 45% reduction in all-cause mortality risk per AHA data.
Female, 41, perimenopausal
She walked in and said: “I just want to feel great in my own skin.” Six months later, with a low-dose GLP-1 plus a 90-day continuous glucose monitor protocol:
Male, 51, third shift
His wife noticed him slowing down. We built a protocol around his irregular schedule. Six months in:
When most people lose weight, their metabolism slows down. His sped up. That is the strength training protocol working.
Sano Longevity is a membership practice, not a single-visit clinic. The results compound over time. Small changes in the first quarter become measurable shifts by the second. Measurable shifts become real outcomes by the end of the year. The patients who stay the longest see the most.
12-month commitment · Gold $299/mo · Elite $499/mo
For patients who want to add years to their life and life to their years. Built around quarterly physician appointments, annual labs, unlimited body composition retesting, concierge access, and an Annual Comprehensive Longevity Evaluation at the end of year one.
Two tiers. Includes medication monitoring for GLP-1s, hormones, peptides, and testosterone therapy if indicated at the Gold level. Elite adds monthly coaching, dietitian, and bi-annual retesting.
12-month commitment · Gold $349/mo · Elite $499/mo
For patients who have tried online GLP-1 prescribers, primary care advice, and diet apps and need a physician with the testing infrastructure to make it work. Built around a 90-day continuous glucose monitor jumpstart, body composition monitoring, and physician-supervised GLP-1 prescribing when clinically appropriate.
Two tiers. Elite adds monthly 1:1 coaching, bi-annual dietitian sessions, and bi-annual metabolic + VO2 max retesting.
Both programs are 12-month commitments with a one-time $350 onboarding and comprehensive assessment fee. Membership-based. HSA and FSA eligible. See our pricing page for the full tier breakdown, or book a free consultation and we will help you pick the right program.
Sano Longevity was built to help anyone who wants to improve the quality and length of their life and we have seen success across a wide range of patients. Here are a few of the patterns we see most often.
You still see yourself the way you did at 22. The mirror is starting to disagree. You want your body composition back, your energy back, and a strength protocol that does not destroy your knees. We give you the data and a plan that fits the life you actually live.
You are doing well professionally and you are watching your mother decline. Dementia is the fear. Strength is the answer. We measure the metabolic markers that drive cognitive aging and build a plan around protecting your brain for the next 30 years.
You finally have the time and the budget to play the long game. You want the next 20 to 30 years to be active, sharp, and on your terms. We build the roadmap that gets you there, and we measure the progress every quarter.
You have done the diets, the apps, the supplements, and the quick-fix programs. You feel reasonably healthy, but you suspect you are not actually optimized and you want a real answer based on real data, not another protocol built by an algorithm. We start with the testing, then build the plan that fits what your numbers actually say.
As Featured In
Speaker, Longevity Fest 2025
Dr. Sweeney spoke at Longevity Fest in December 2025, the largest annual longevity medicine conference in the United States, organized by the American Academy of Anti-Aging Medicine.
A growing share of our patients cross the bridge from Jeffersonville and New Albany in Southern Indiana, where there is no comparable longevity medicine practice. The drive is 15 to 20 minutes.
Seven questions patients ask most often before booking their first visit.
Longevity medicine identifies the precursors to chronic disease 10 to 20 years before they show up on a standard lab. Traditional healthcare treats what is already broken. SANO Longevity uses advanced testing and data-driven insights to deliver truly personalized care: VO2 max, resting metabolic rate, body composition, visceral fat, and a 46-marker longevity lab panel that includes fasting insulin and the Omega-3 index building an individualized plan to reverse risk before it becomes diagnosis.
Dr. Meredith Sweeney is a board-certified bariatric surgeon (MD, FACS, FASMBS) who spent over a decade operating on the consequences of metabolic disease before founding Sano Longevity in March 2025. She is a member of the American Academy of Anti-Aging Medicine and spoke at Longevity Fest in December 2025, the largest annual longevity medicine conference in the United States. Read her full story →
Sano Longevity is a membership-based practice. Insurance is not accepted. The practice is HSA and FSA eligible, and payment is by credit card or cash. This model exists so Dr. Sweeney can spend 60 to 90 minutes with you reviewing your data instead of the 12 minutes a typical insurance-billed visit allows.
Your first visit is fasted and in-office. You complete VO2 max testing on a bike or treadmill (under 15 minutes), an InBody 580 body composition scan, resting metabolic rate testing on the PNOĒ platform, and a blood draw that runs through Quest Diagnostics. About one month later, Dr. Sweeney spends 60 to 90 minutes walking you through every result and presenting your individualized longevity roadmap.
Fasting insulin is the most important biomarker of longevity. It rises years before fasting glucose moves, but standard primary care panels almost never include it.
By calculating cardiorespiratory fitness, body composition and an extensive lab panel. Dr. Sweeney identifies the pre-cursers to the chronic diseases of aging like cardiovascular disease, dementia, diabetes, cancer, and alzeimers.
Sano Longevity is located at 306 Middletown Park Pl Unit D, Louisville, KY 40243, in the heart of Louisville’s eastern corridor. Patients drive in from across the metro and across the river from Norton Commons, St. Matthews, Mockingbird Valley, Indian Hills, Anchorage, Prospect, Lake Forest, Pewee Valley, and from Jeffersonville and New Albany in Southern Indiana. Patients also travel from Lexington, Cincinnati, and Indianapolis. Only your first appointment needs to be in person everything after can be virtual.
Sano Longevity offers two membership programs. The Longevity Optimization Program is a 12-month commitment with two tiers: Gold ($299/mo) and Elite ($499/mo). The Weight Loss Program is a 12-month commitment with two tiers: Gold ($349/mo) and Elite ($499/mo). A one-time $350 onboarding and comprehensive assessment fee applies to all programs. See the pricing page →
Your first call is free, 30 minutes, and answered by someone who can tell you whether Sano is the right fit before you commit a dollar. Concierge practice. HSA and FSA eligible. Same physician every visit.
We respond within 24 hours. No pitch. Just data. Or call (502) 208-6476.
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Reviewed by
Founder, Sano Longevity in Middletown, Louisville. Board-certified bariatric surgeon. Fellow of the American College of Surgeons (FACS) and the American Society for Metabolic and Bariatric Surgery (FASMBS). Member, American Academy of Anti-Aging Medicine (A4M). Speaker, Longevity Fest 2025. More than ten years of metabolic medicine experience at Norton Healthcare before founding Sano Longevity in March 2025.
Sano Longevity
(502) 208-6476
